If colon cancer is at a very early stage, it may be possible to remove just a small piece of the lining of the colon wall, known as local excision. We can even find you a free ride to treatment or a free place to stay when treatment is far from home. National Cancer Institute. Stage IV and recurrent colon cancer treatment. Learn more about these partnerships and how you too can join us in our mission to save lives, celebrate lives, and lead the fight for a world without cancer. Chemotherapy may also be used after surgery (called adjuvant treatment). Whether you want to learn about treatment options, get advice on coping with side effects, or have questions about health insurance, we’re here to help. Targeted therapy drugs used to treat colorectal cancer include: You may want to consider a type of care to make you feel better without treating the cancer itself. Removing part of the colon (partial colectomy) may be needed if a cancer is too big to be removed by local excision. Surgery is the most common medical treatment for colorectal cancer. Chapter 74 – Colorectal Cancer. For people with certain tumor changes in the MMR genes, another option after initial chemotherapy might be treatment with an immunotherapy drug such as pembrolizumab (Keytruda) or nivolumab (Opdivo). Talk to your healthcare team. Surgery is the only curative modality for localized colon cancer (stage I-III). In most cases this can be done by removing the polyp or taking out the area with cancer through a colonoscope (local excision). Colon Cancer Treatment options depend on where the tumour is in the colon, how big it is and if it has grown or spread outside of the original site. This is called neoadjuvant therapy. Cancer.org is provided courtesy of the Leo and Gloria Rosen family. Canada’s only young adult colorectal cancer clinic. Find out more about clinical trials. If the cancer can’t be removed surgically, chemo might be tried first. Depending on the type of colorectal cancer, different types of drugs might be used, such as: Chemotherapy for Colorectal Cancer The first-line treatment for colon cancer at stages zero or one is surgery to remove the affected part of the colon. The latest Canadian Cancer Statistics report found that of all newly diagnosed cancers in 2017, half are expected to be lung, colorectal, breast and prostate cancers. There are different treatments for colon cancer and rectal cancer. Chemo might be given again after surgery. Libutti SK, Saltz LB, Willett CG, and Levine RA. These tests also help your doctors decide on the most effective treatment for you. We do not endorse non-Cleveland Clinic products or services. Cleveland Clinic is a non-profit academic medical center. In: Niederhuber JE, Armitage JO, Dorshow JH, Kastan MB, Tepper JE, eds. Or write us. Cancer Information, Answers, and Hope. Colon cancer is a type of cancer that begins in the large intestine (colon). Chemotherapy drugs used alone or in combination to treat colorectal cancer include: Leucovorin (folinic acid) is a common drug used in treating colorectal cancer. It usually begins as small, noncancerous (benign) clumps of cells called polyps that form on the inside of the colon. Stage I colon cancers have grown deeper into the layers of the colon wall, but they have not spread outside the colon wall itself or into the nearby lymph nodes. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. If the cancer comes back in a distant site, it's most likely to appear in the liver first. Whether you or someone you love has cancer, knowing what to expect can help you cope. Sci Rep. 2016;6:29765. doi:10.1038/srep29765 enews. This might be followed by more chemo. More information: Marloes Zoetemelk et al, Optimized low‐dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment, Molecular Oncology (2020). 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